While many are calling Alli a weight loss breakthrough, we remain a bit skeptical. Why? Because…the question is, is Alli really safe and effective?

Alli’s History

For the first time, the FDA has approved a weight-loss drug that’s to be sold over the counter. Called Alli, the product is a less potent version of the fat-blocking prescription drug Xenical.

Alli is slated to hit stores this summer at a cost of about $60 per month, and thanks to a powerful advertising blitz, financial analysts predict its sales will total several hundred million dollars per year.

Is Alli the answer to dieters’ prayers, or is it just hype? Here, what you should know before considering this slimming option.

The Science Behind Alli

Clinical studies show that taking Alli three times daily with reduced-calorie, low-fat meals results in a 5 to 15 percent drop in weight in six months.

The drug works by binding to fat-digesting enzymes in the intestines, thus preventing the gut from absorbing about 30 percent of a meal’s dietary fat. Instead, this fat is quickly eliminated via the bowels.

Alli’s Possible Side Effects

One-third of Alli consumers may experience gastrointestinal problems like diarrhea, spontaneous oily discharge, flatulence with discharge and oily stool, according to the company’s studies.

Another concern: Alli blocks absorption of fat-soluble vitamins like A, D, E, K and beta-carotene, which are key to many physiological functions, including energy, metabolism and immunity.

That’s why it’s recommended that Alli users also take a multivitamin with meals.

Despite this, symptoms of nutrient deprivation like fatigue, joint and muscle pain, sleeplessness, increased risk of respiratory and kidney infections, menstrual problems and vaginal inflammation were reported in trials. [source: First]